This Article Full Text (PDF) Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rankin, S C Articles by Cook, G J R Search for Related Content PubMed Articles by Rankin, S C Articles by Cook, G J R

Lymphoma: monitoring response to therapy

Department of Radiology, Guy's Hospital, Guy's and St Thomas' Trust, St Thomas Street, London SE1 9RT, UK
Department of Nuclear Medicine, Guy's Hospital, Guy's and St Thomas' Trust, St Thomas Street, London SE1 9RT, UK

Summary

• Residual masses are found in up to 85% of patients with Hodgkin's disease that responds to therapy. Most occur in the mediastinum.
  
• Thymic hyperplasia can follow chemotherapy in both children and adults.
  
• Residual masses occur in 40% of patients with non-Hodgkin's lymphoma.
  
• Residual masses consist of fibrosis and necrotic tissue but viable tumour may remain.
  
• CT cannot differentiate fibrosis from viable tumour.
  
• MRI using T₂ weighted sequences may be able to identify viable tissue within fibrosis.
  
• Gallium and PET can be used to both identify residual tumour and to predict response to therapy.