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Extrapulmonary complications of bone marrow transplantation

Department of Radiology, Royal Marsdens Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK

• The nature and course of complication in bone marrow transplantation (BMT) are affected by many factors including: the host, the transplant and treatment regimens used.
  
• The primary complication of BMT is graft-versus-host disease (GVHD) where T-cells from the donor marrow produce an immune response against host tissue in the patient's skin, liver and gastrointestinal tract.
  
• The main complications of high-dose chemotherapy include infections and hepatic veno-occlusive disease (HVOD).
  
• Late complication following BMT include second malignancy, avascular necrosis and endocrine dysfunctions.
  

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